Šeško is awaiting tests after another setback, leaving his United return uncertain before Tottenham.
Chelsea’s summer arrivals have produced mixed returns under Xabi Alonso after five Premier League matches.
Palmer’s England setback may disappoint him, but Chelsea can benefit from his extra rest.
Šeško missed United’s visit to Fulham while Carrick waits on an injury assessment.
Townsend was run over by a pitch roller in Thailand, but escaped with minor injuries.
Chelsea's early defensive record under Xabi Alonso has joined an unwanted Premier League list.
Brentford’s discipline and Chelsea’s injuries exposed deeper flaws in Alonso’s side at the Gtech.
Chelsea travel to Brentford without João Pedro, with injury doubts also affecting Reece James and Moisés Caicedo.
João Pedro’s knee problem could keep him out for around three-and-a-half weeks.
Pedro is still available for Chelsea’s Brentford test, with Alonso delaying a final fitness call until Friday.